3-AMINO-4H-BENZO[E][1,2,4]THIADIAZINE 1,1-DIOXIDE DERIVATIVES AS INHIBITORS OF MRGX2

Disclosed are compounds of Formula (1), tautomers thereof, and pharmaceutically acceptable salts of the compounds or tautomers, wherein L, R1, R2, R3, R4 and R5 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula (1), to pharmace...

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Bibliographische Detailangaben
Hauptverfasser:	PICKENS, JASON, BIGI, SIMONE, VASSAR, ANGIE, SHIOKAWA, ZENYU, GIBSON, TONY, SWANN, STEVE, SETO, MASAKI, CHAMBERS, ALLISON L, ZHOU, FENG, KONO, MITSUNORI
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are compounds of Formula (1), tautomers thereof, and pharmaceutically acceptable salts of the compounds or tautomers, wherein L, R1, R2, R3, R4 and R5 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula (1), to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders or conditions associated with MRGX2. L'invention concerne des composés de formule (1), des tautomères correspondants et des sels pharmaceutiquement acceptables des composés ou tautomères, L, R1, R2, R3, R4 et R5 étant définis dans la description. La présente invention concerne également des matériels et des procédés pour préparer les composés de formule (1), des compositions pharmaceutiques les contenant et leur utilisation pour le traitement de maladies, de troubles ou d'états pathologiques associés au MRGX2.