TECHNOLOGIES USEFUL FOR OLIGONUCLEOTIDE PREPARATION

TECHNOLOGIES USEFUL FOR OLIGONUCLEOTIDE PREPARATION

Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs. Entre autres, la présente...

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Hauptverfasser: KUMARASAMY, JAYAKANTHAN, BOWMAN, KEITH ANDREW, VARGEESE, CHANDRA, STANDLEY, STEPHANY MICHELLE, BUTLER, DAVID CHARLES DONNELL, BOMMINENI, GOPAL REDDY, BHATTARAI, BIJAY TILAK, DIVAKARAMENON, SETHUMADHAVAN, KANDASAMY, PACHAMUTHU, SHIMIZU, MAMORU, ALAM, MOHAMMED ROWSHON
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs. Entre autres, la présente invention concerne des technologies pour la préparation d'oligonucléotides, en particulier la préparation d'oligonucléotides à commande chirale, lesquelles technologies fournissent une pureté et un rendement bruts considérablement améliorés, et réduisent significativement les coûts de fabrication.