METHOD FOR THE IN VIVO SYNTHESIS OF 4-HYDROXYMETHYLFURFURAL AND DERIVATIVES THEREOF

The present disclosure provides recombinant microorganisms and methods for the production of 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA from a carbon source. The method provides for eng...

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Bibliographische Detailangaben
Hauptverfasser:	ESTRADA GOUVEA, IURI, LEITE QUEIROZ, VERONICA, RADUAN ALEXANDRINO, PAULO MOISES
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure provides recombinant microorganisms and methods for the production of 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA from a carbon source. The method provides for engineered microorganisms that express endogenous and/or exogenous nucleic acid molecules that catalyze the conversion of a carbon source into 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA. The disclosure further provides methods of producing polymers derived from 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA. La présente invention concerne des micro-organismes recombinés et des procédés pour la production De 4-HMF, 2,4-furandiméthanol, furan-2,4-dicarbaldéhyde, l'acide-4-(hydroxyméthyl)furoïque, le 2-formylfurane-4-carboxylate, le 4-formylfurane-2-carboxylate et/ou le 2,4-FDCA à partir d'une source de carbone. Le procédé fournit des micro-organismes génétiquement modifiés exprimant des molécules d'acide nucléique endogène et/ou exogène qui catalysent la conversion d'une source de carbone en 4-HMF, 2,4-furandiméthanol, furan-2,4-dicarbaldéhyde, l'acide-4-(hydroxyméthyl)furoïque, le 2-formylfurane-4-carboxylate, le 4-formylfurane-2-carboxylate et/ou le 2,4-FDCA. L'invention concerne en outre des procédés de production de polymères dérivés de 4-HMF, 2,4-furandiméthanol, furan-2,4-dicarbaldéhyde, l'acide-4-(hydroxyméthyl)furoïque, le 2-formylfurane-4-carboxylate, le 4-formylfurane-2-carboxylate et/ou le 2,4-FDCA.