INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES

INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES

88969137 ABSTRACT The present invention relates to methods of synthesizing calicheamicin derivatives, such as calicheamicin derivatives of Formula VI R8v (R9 H H 1 0 tyN,N Ar-VV-YZ Formula Vl which method comprises reacting a linker intermediate of Formula V R8 R9 H H 1 0 HS> NC(NyN,., Ar-W-Y)LZ...

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Bibliographische Detailangaben
Hauptverfasser: DUGGER, ROBERT WAYNE, PRASHAD, AMARNAUTH SHASTRIE, LETENDRE, LEO JOSEPH, ZHANG, CHUNCHUN, PATEL, VIMALKUMAR BABUBHAI
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PEPTIDES
SUGARS
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Zusammenfassung:88969137 ABSTRACT The present invention relates to methods of synthesizing calicheamicin derivatives, such as calicheamicin derivatives of Formula VI R8v (R9 H H 1 0 tyN,N Ar-VV-YZ Formula Vl which method comprises reacting a linker intermediate of Formula V R8 R9 H H 1 0 HS> NC(NyN,., Ar-W-Y)LZ Formula V = with a methyltrisulfide compound CH3-S-S-S-J, in the presence of a carbodiimide; thereby synthesizing a calicheamicin derivative of Formula VI. Date Recue/Date Received 2021-09-22