SUBSTITUTED HETEROCYCLIC AMIDE COMPOUND AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF

Provided are a substituted heterocyclic amide compound having a selective inhibitory effect on RIPK1, and a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof, and a pharmaceutical composition containing the compound, and the use of same in the preparation of a drug for...

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Bibliographische Detailangaben
Hauptverfasser:	LV, QIANG, ZHENG, BIAO, XU, XIAOMING, ZHANG, LEITAO, HU, GANG, LIU, ZHUBO, XIE, FUBO, DING, QIAN, LAN, JIONG, ZHOU, FUSHENG
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Provided are a substituted heterocyclic amide compound having a selective inhibitory effect on RIPK1, and a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof, and a pharmaceutical composition containing the compound, and the use of same in the preparation of a drug for treating a RIPKI-related diseases or conditions. The compound has a structure as represented by formula (I) or (II): (see formula II) L'invention concerne un composé amide hétérocyclique substitué ayant un effet inhibiteur sélectif sur RIPK1, et un sel pharmaceutiquement acceptable, un stéréoisomère, un solvate ou un promédicament de celui-ci, et une composition pharmaceutique contenant le composé, et leur utilisation dans la préparation d'un médicament pour le traitement de maladies ou d'états liés à RIPK1.