HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS

Disclosed herein are certain acetamido derivatives that are DNA Polymerase Theta (Pol?) inhibitors of Formula (I). Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of Pol? such as cancer, including homologous recombina...

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Bibliographische Detailangaben
Hauptverfasser:	BECK, HILARY PLAKE, MARTINEZ, LUISRUBEN P, JONES, BRIAN, DILLON, MICHAEL
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein are certain acetamido derivatives that are DNA Polymerase Theta (Pol?) inhibitors of Formula (I). Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of Pol? such as cancer, including homologous recombination (HR) deficient cancers. L'invention concerne certains dérivés acétamido qui sont des inhibiteurs d'ADN polymérase thêta (Pol?) de formule (I). L'invention concerne également des compositions pharmaceutiques comprenant de tels composés et des méthodes de traitement de maladies pouvant être traitées par inhibition de Pol? telles que le cancer, y compris des cancers déficients en recombinaison homologue (HR).