METHODS OF PRODUCING HIGH DIVERSITY PEPTIDE LIBRARIES AND PROMOTING PROTEIN FOLDING

METHODS OF PRODUCING HIGH DIVERSITY PEPTIDE LIBRARIES AND PROMOTING PROTEIN FOLDING

The disclosure provides a peptide library with increased peptide diversity. The increase in peptide diversity can occur via cleavage of particular amino acids within a peptide. The disclosure further provides a method for promoting folding of a peptide into an active conformation. L'invention c...

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Bibliographische Detailangaben
Hauptverfasser: AFZELIUS, ELLEN LOVISA LARSDOTTER, YOSEFSON, OHAD, ROSCOE, BENJAMIN PETER, MABRY, GEORGE ROBERT III, ROGOV, PETER LYUBOMIROV, VAIDYA, HARSH JAYESHKUMAR, SWAIN, JOANNA FELTHAM
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
COMBINATORIAL CHEMISTRY
LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The disclosure provides a peptide library with increased peptide diversity. The increase in peptide diversity can occur via cleavage of particular amino acids within a peptide. The disclosure further provides a method for promoting folding of a peptide into an active conformation. L'invention concerne une banque peptidique ayant une diversité de peptides accrue. L'augmentation de la diversité de peptides peut se produire par clivage d'acides aminés particuliers dans un peptide. L'invention concerne en outre un procédé permettant de favoriser le pliage d'un peptide dans une conformation active.