HISTONE ACETYLASE P300 INHIBITOR AND USE THEREOF

Provided are a histone acetylase p300 inhibitor and a use thereof, belonging to the field of medicinal chemistry technology. A compound represented by formula (I), or a stereochemical isomer thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof, can inhibit the activity of his...

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Bibliographische Detailangaben
Hauptverfasser:	HUO, YONGXU, ZHANG, CHENGZHI, FAN, LEI, TU, ZHILIN, WANG, FEI, XU, KEXIN, LUO, TONGCHUAN, DU, WU, CHEN, YUANWEI, LI, XINGHAI, ZHANG, SHAOHUA, WU, XIAOQUAN, CHEN, KE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided are a histone acetylase p300 inhibitor and a use thereof, belonging to the field of medicinal chemistry technology. A compound represented by formula (I), or a stereochemical isomer thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof, can inhibit the activity of histone acetylase p300 and inhibit the proliferation activity of a variety of tumor cells. L'invention concerne un inhibiteur d'histone acétylase p300 et son utilisation, se rapportant au domaine de la technologie de chimie médicinale. L'invention concerne un composé représenté par la formule (I), ou un isomère stéréochimique, ou un solvate, ou un sel pharmaceutiquement acceptable de celui-ci, qui peut inhiber l'activité de l'histone acétylase p300 et l'activité de prolifération d'une variété de cellules tumorales. Drawing_references_to_be_translated: