NOVEL IMIDAZOLE DERIVATIVE

The present invention provides a novel imidazole derivative or a pharmaceutically acceptable salt thereof. The novel imidazole derivative, which is represented by general formula [1] or [2], demonstrates, through a LpxC inhibition action, a strong anti-bacterial activity against gram-negative bacter...

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Bibliographische Detailangaben
Hauptverfasser:	OGATA, YUYA, USHIYAMA, FUMIHITO, SASAMOTO, NAOKI, TAKASHIMA, HAJIME, TSURUTA, RISA, MATSUDA, YOHEI, TANAKA, NOZOMI, UEKI, KAORI
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides a novel imidazole derivative or a pharmaceutically acceptable salt thereof. The novel imidazole derivative, which is represented by general formula [1] or [2], demonstrates, through a LpxC inhibition action, a strong anti-bacterial activity against gram-negative bacteria such as Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae, and drug-resistant strains thereof. La présente invention concerne un nouveau dérivé d'imidazole ou un sel pharmaceutiquement acceptable de celui-ci. Le nouveau dérivé d'imidazole, qui est représenté par la formule générale [1] ou [2], démontre, par une action d'inhibition de LpxC, une forte activité anti-bactérienne contre les bactéries à gram négatif telles que Pseudomonas aeruginosa, Escherichia coli et Klebsiella pneumoniae et des souches de celles-ci résistantes aux médicaments.