ANTIBODY CONSTRUCTS BINDING 4-1BB AND TUMOR-ASSOCIATED ANTIGENS AND USES THEREOF

Described herein are antibody constructs comprising a 4-1BB binding domain and an antigen-binding domain that binds to a tumor-associated antigen (TAA), wherein the 4-lBB-binding domain and the TAA antigen-binding domain are linked directly or indirectly to a scaffold. The scaffold may be an Fc cons...

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Bibliographische Detailangaben
Hauptverfasser:	CHUI, DANNY, SPRETER VON KREUDENSTEIN, THOMAS, PATTON, DANIEL T, PRATAP, HARSH, CHAN, PETER WING YIU, HALVORSEN, ELIZABETH, ZWIERZCHOWSKI, PATRICIA, MILLS, DAVID M, GENE, ROBERT WILLIAM, CLAVETTE, BRANDON, VON ROSSUM, ANNA, BROWMAN, DUNCAN, FREIBURGER, LEE, VOLKERS, GESA, UROSEV, DUNJA, DUAN, ZHUANG, JANCOWSKI, SYLWIA, KANG, SUKHBIR SINGH
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Described herein are antibody constructs comprising a 4-1BB binding domain and an antigen-binding domain that binds to a tumor-associated antigen (TAA), wherein the 4-lBB-binding domain and the TAA antigen-binding domain are linked directly or indirectly to a scaffold. The scaffold may be an Fc construct with modifications that reduce its ability to mediate effector function. L'invention concerne des constructions d'anticorps comprenant un domaine de liaison à 4-1BB et un domaine de liaison à l'antigène qui se lie à un antigène associé à une tumeur (TAA), le domaine de liaison à 4-1BB et le domaine de liaison à l'antigène TAA étant liés directement ou indirectement à un échafaudage. L'échafaudage peut être une construction Fc avec des modifications qui réduisent sa capacité à médier la fonction effectrice.