BCMA CHIMERIC ANTIGEN RECEPTOR BASED ON SINGLE DOMAIN ANTIBODY AND USE THEREOF

A chimeric antigen receptor (CAR) and the use thereof, the CAR comprising: a BCMA binding domain, a transmembrane domain, one or more co-stimulatory domains, and an intracellular signaling domain, wherein the BCMA binding domain comprises heavy chain complementarity determining regions HCDR1-3, and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	BAO, CHAOLEMENG, SU, HONGCHANG, ZHANG, JISHUAI, CAI, QINGHUA, CAI, ZHIBO, LI, HONGJIAN, SONG, ZONGPEI, DING, YIJIN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A chimeric antigen receptor (CAR) and the use thereof, the CAR comprising: a BCMA binding domain, a transmembrane domain, one or more co-stimulatory domains, and an intracellular signaling domain, wherein the BCMA binding domain comprises heavy chain complementarity determining regions HCDR1-3, and the amino acid sequences of the HCDR1-3 are successively as shown in SEQ ID NO: 1-3. L'invention concerne un récepteur antigénique chimérique (CAR) et son utilisation, le CAR comprenant : un domaine de liaison BCMA, un domaine transmembranaire, un ou plusieurs domaines de co-stimulation, et un domaine de signalisation intracellulaire, le domaine de liaison BCMA comprenant des régions de détermination de la complémentarité de chaîne lourde HCDR1-3, et les séquences d'acides aminés de HCDR1-3 étant successivement représentées dans SEQ ID NO : 1-3.