PROCESS AND INTERMEDIATES FOR THE PREPARATION OF BILASTINE

PROCESS AND INTERMEDIATES FOR THE PREPARATION OF BILASTINE

The invention relates to a process for preparing a compound of (III) wherein X is a leaving group; and R1 is C1-C6 alkyl; which comprises oxidative rearrangement of a compound of formula (II) or a solvate thereof Compounds of formula (III) are key intermediates in the synthesis of Bilastine. L'...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GONZALEZ GARCIA, TANIA, MORAN POLADURA, PABLO, HERNANDEZ HERRERO, GONZALO, GARCIA DOMINGUEZ, NEFTALI, GANZA GONZALEZ, ALVARO, TATO CERDEIRAS, PALOMA
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to a process for preparing a compound of (III) wherein X is a leaving group; and R1 is C1-C6 alkyl; which comprises oxidative rearrangement of a compound of formula (II) or a solvate thereof Compounds of formula (III) are key intermediates in the synthesis of Bilastine. L'invention concerne un procédé de préparation d'un composé (III), X étant un groupe partant ; et R1 étant un alkyle en C1-C6 ; qui comprend un réarrangement oxydatif d'un composé de formule (II) ou d'un solvate de celui-ci, les composés de formule (III) sont des intermédiaires clés dans la synthèse de la bilastine.