CELL CULTURE STRATEGIES FOR MODULATING PROTEIN GLYCOSYLATION

The presently disclosed subject matter relates to cell culture media and cell culture strategies for modulating the glycosylation pattern, e.g., fucosylation and/or galactosylation pattern, of a glycoprotein of interest, e.g., an antibody, as well as cell culture and glycoprotein compositions prepar...

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Bibliographische Detailangaben
Hauptverfasser:	AHYOW, PATRICK DANIEL, NGUYEN DANG, ANH THUY, DOUGLAS, KRISTEN LEIGH, YUK, INN HUAM, MUN, MELISSA SIU-LAN, KISS, ROBERT DAVID
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The presently disclosed subject matter relates to cell culture media and cell culture strategies for modulating the glycosylation pattern, e.g., fucosylation and/or galactosylation pattern, of a glycoprotein of interest, e.g., an antibody, as well as cell culture and glycoprotein compositions prepared using such media and/or strategies. La présente invention concerne des milieux de culture cellulaire et des stratégies de culture cellulaire pour moduler le motif de glycosylation, par exemple, un motif de fucosylation et/ou de galactosylation, d'une glycoprotéine d'intérêt, par exemple, un anticorps, ainsi que des compositions de culture cellulaire et de glycoprotéines préparées à l'aide de tels milieux et/ou stratégies.