OPTIMISED DOSAGE OF DIAMINOPHENOTHIAZINES IN POPULATIONS
The invention provides novel dosing regimens for Leuco-Methylthioninium (LMT) compounds which maximise the proportion of subjects in which the MT concentration will exceed concentrations in which therapeutic efficacy in relation to treatment of neurodegenerative disorders such as Alzheimer's di...
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| creator | SHIELLS, HELEN CHRISTINE WISCHIK, CLAUDE MICHEL SCHELTER, BJORN OLAF |
| description | The invention provides novel dosing regimens for Leuco-Methylthioninium (LMT) compounds which maximise the proportion of subjects in which the MT concentration will exceed concentrations in which therapeutic efficacy in relation to treatment of neurodegenerative disorders such as Alzheimer's disease and rontotemporal dementias can be achieved, while maintaining a desirable clinical profile. Also provided are LMT- containing dosage units and other compositions.
L'invention concerne de nouveaux régimes posologiques pour composés Leuco-Méthylthioninium (LMT) qui maximisent la proportion de sujets dans lesquels la concentration en MT va dépasser des concentrations dans lesquelles l'efficacité thérapeutique en relation avec le traitement de troubles neurodégénératifs tels que la maladie d'Alzheimer et les démences rontotemporales peut être obtenue, tout en maintenant un profil clinique souhaitable. L'invention concerne également des unités de dosage contenant du LMT et d'autres compositions. |
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L'invention concerne de nouveaux régimes posologiques pour composés Leuco-Méthylthioninium (LMT) qui maximisent la proportion de sujets dans lesquels la concentration en MT va dépasser des concentrations dans lesquelles l'efficacité thérapeutique en relation avec le traitement de troubles neurodégénératifs tels que la maladie d'Alzheimer et les démences rontotemporales peut être obtenue, tout en maintenant un profil clinique souhaitable. L'invention concerne également des unités de dosage contenant du LMT et d'autres compositions.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200130&DB=EPODOC&CC=CA&NR=3106152A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200130&DB=EPODOC&CC=CA&NR=3106152A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SHIELLS, HELEN CHRISTINE</creatorcontrib><creatorcontrib>WISCHIK, CLAUDE MICHEL</creatorcontrib><creatorcontrib>SCHELTER, BJORN OLAF</creatorcontrib><title>OPTIMISED DOSAGE OF DIAMINOPHENOTHIAZINES IN POPULATIONS</title><description>The invention provides novel dosing regimens for Leuco-Methylthioninium (LMT) compounds which maximise the proportion of subjects in which the MT concentration will exceed concentrations in which therapeutic efficacy in relation to treatment of neurodegenerative disorders such as Alzheimer's disease and rontotemporal dementias can be achieved, while maintaining a desirable clinical profile. Also provided are LMT- containing dosage units and other compositions.
L'invention concerne de nouveaux régimes posologiques pour composés Leuco-Méthylthioninium (LMT) qui maximisent la proportion de sujets dans lesquels la concentration en MT va dépasser des concentrations dans lesquelles l'efficacité thérapeutique en relation avec le traitement de troubles neurodégénératifs tels que la maladie d'Alzheimer et les démences rontotemporales peut être obtenue, tout en maintenant un profil clinique souhaitable. L'invention concerne également des unités de dosage contenant du LMT et d'autres compositions.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLDwDwjx9PUMdnVRcPEPdnR3VfB3U3DxdPT19PMP8HD18w_x8HSM8vRzDVbw9FMI8A8I9XEM8fT3C-ZhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfHOjsaGBmaGpkaOhsZEKAEANqAoPg</recordid><startdate>20200130</startdate><enddate>20200130</enddate><creator>SHIELLS, HELEN CHRISTINE</creator><creator>WISCHIK, CLAUDE MICHEL</creator><creator>SCHELTER, BJORN OLAF</creator><scope>EVB</scope></search><sort><creationdate>20200130</creationdate><title>OPTIMISED DOSAGE OF DIAMINOPHENOTHIAZINES IN POPULATIONS</title><author>SHIELLS, HELEN CHRISTINE ; WISCHIK, CLAUDE MICHEL ; SCHELTER, BJORN OLAF</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3106152A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2020</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SHIELLS, HELEN CHRISTINE</creatorcontrib><creatorcontrib>WISCHIK, CLAUDE MICHEL</creatorcontrib><creatorcontrib>SCHELTER, BJORN OLAF</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SHIELLS, HELEN CHRISTINE</au><au>WISCHIK, CLAUDE MICHEL</au><au>SCHELTER, BJORN OLAF</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>OPTIMISED DOSAGE OF DIAMINOPHENOTHIAZINES IN POPULATIONS</title><date>2020-01-30</date><risdate>2020</risdate><abstract>The invention provides novel dosing regimens for Leuco-Methylthioninium (LMT) compounds which maximise the proportion of subjects in which the MT concentration will exceed concentrations in which therapeutic efficacy in relation to treatment of neurodegenerative disorders such as Alzheimer's disease and rontotemporal dementias can be achieved, while maintaining a desirable clinical profile. Also provided are LMT- containing dosage units and other compositions.
L'invention concerne de nouveaux régimes posologiques pour composés Leuco-Méthylthioninium (LMT) qui maximisent la proportion de sujets dans lesquels la concentration en MT va dépasser des concentrations dans lesquelles l'efficacité thérapeutique en relation avec le traitement de troubles neurodégénératifs tels que la maladie d'Alzheimer et les démences rontotemporales peut être obtenue, tout en maintenant un profil clinique souhaitable. L'invention concerne également des unités de dosage contenant du LMT et d'autres compositions.</abstract><oa>free_for_read</oa></addata></record> |
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| title | OPTIMISED DOSAGE OF DIAMINOPHENOTHIAZINES IN POPULATIONS |
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