OPTIMISED DOSAGE OF DIAMINOPHENOTHIAZINES IN POPULATIONS

The invention provides novel dosing regimens for Leuco-Methylthioninium (LMT) compounds which maximise the proportion of subjects in which the MT concentration will exceed concentrations in which therapeutic efficacy in relation to treatment of neurodegenerative disorders such as Alzheimer's di...

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Bibliographische Detailangaben
Hauptverfasser:	SHIELLS, HELEN CHRISTINE, WISCHIK, CLAUDE MICHEL, SCHELTER, BJORN OLAF
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides novel dosing regimens for Leuco-Methylthioninium (LMT) compounds which maximise the proportion of subjects in which the MT concentration will exceed concentrations in which therapeutic efficacy in relation to treatment of neurodegenerative disorders such as Alzheimer's disease and rontotemporal dementias can be achieved, while maintaining a desirable clinical profile. Also provided are LMT- containing dosage units and other compositions. L'invention concerne de nouveaux régimes posologiques pour composés Leuco-Méthylthioninium (LMT) qui maximisent la proportion de sujets dans lesquels la concentration en MT va dépasser des concentrations dans lesquelles l'efficacité thérapeutique en relation avec le traitement de troubles neurodégénératifs tels que la maladie d'Alzheimer et les démences rontotemporales peut être obtenue, tout en maintenant un profil clinique souhaitable. L'invention concerne également des unités de dosage contenant du LMT et d'autres compositions.