OLIGONUCLEOTIDES COMPRISING A PHOSPHOROTRITHIOATE INTERNUCLEOSIDE LINKAGE

The present invention relates to an oligonucleotide comprising at least one phosphorotrithioate internucleoside linkage of formula (I), wherein (A1), (A2) and R are as defined in the description and in the claim. The oligonucleotide of the invention can be used as a medicament. La présente invention...

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Bibliographische Detailangaben
Hauptverfasser:	KOCH, TROELS, DUSCHMALE, JOERG JAKOB ANDREAS, DUSCHMALE, MARTINA BRIGITTE, BLEICHER, KONRAD, LI, MEILING, KOLLER, ERICH, SCHAEUBLIN, ADRIAN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	The present invention relates to an oligonucleotide comprising at least one phosphorotrithioate internucleoside linkage of formula (I), wherein (A1), (A2) and R are as defined in the description and in the claim. The oligonucleotide of the invention can be used as a medicament. La présente invention concerne un oligonucléotide comprenant au moins une liaison internucléosidique phosphorotrithioate de formule (I), dans laquelle (A1), (A2) et R sont tels que définis dans la description et dans la revendication. L'oligonucléotide de l'invention peut être utilisé en tant que médicament.