PHOSPHATE AND PHOSPHONATE DERIVATIVES OF 7-AMINO-5-THIO-THIAZOLO[4,5-D]PYRIMIDINES AND THEIR USE IN TREATING CONDITIONS ASSOCIATED WITH ELEVATED LEVELS OF CX3CR1 AND/OR CX3CL1

There is provided a compound of formula (I), wherein R1, R2, Q1 and formula (X) are as defined herein, which compounds are useful in the treatment of diseases and disorders associated with elevated levels of CX3CR1 and/or CX3CL1, in particular acute and/or chronic inflammation, eye diseases, lung di...

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Bibliographische Detailangaben
Hauptverfasser:	BYSTROM, STYRBJORN, VAGBERG, JAN, OLSSON, ELISABETH, JONSSON, MATTIAS
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	There is provided a compound of formula (I), wherein R1, R2, Q1 and formula (X) are as defined herein, which compounds are useful in the treatment of diseases and disorders associated with elevated levels of CX3CR1 and/or CX3CL1, in particular acute and/or chronic inflammation, eye diseases, lung diseases, skin diseases, joint and/or bone diseases, autoimmune diseases, cardiovascular diseases, metabolic diseases, brain diseases, neurodegenerative diseases, pain, cancer, liver diseases, kidney diseases, gastrointestinal diseases, human immunodeficiency virus and mood disorders. L'invention concerne un composé de formule (I), dans laquelle R1, R2, Q1 et la formule (X) sont tels que définis dans la description, lesdits composés étant utiles dans le traitement de maladies et de troubles associés à des niveaux élevés de CX3CR1 et/ou CX3CL1, en particulier une inflammation aiguë et/ou chronique, des maladies oculaires, des maladies pulmonaires, des maladies cutanées, des maladies articulaires et/ou osseuses, des maladies auto-immunes, des maladies cardiovasculaires, des maladies métaboliques, des maladies cérébrales, des maladies neurodégénératives, la douleur, le cancer, des maladies hépatiques, des maladies rénales, des maladies gastro-intestinales, le virus de l'immunodéficience humaine et des troubles de l'humeur.