2-AMINO-PYRIDINE OR 2-AMINO-PYRIMIDINE DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS

2-AMINO-PYRIDINE OR 2-AMINO-PYRIMIDINE DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS

This invention relates to compounds of Formula (I),or a pharmaceutically acceptable salt thereof, in which R-groups R1 to R23, A, Q, U, V, W, X, Y, Z, n, p and q are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts a...

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Bibliographische Detailangaben
Hauptverfasser: CHO-SCHULTZ, SUJIN, DEAL, JUDITH GAIL, KANIA, ROBERT STEVEN, NAIR, SAJIV KRISHNAN, GALLEGO, GARY MICHAEL, CHEN, PING, PALMER, CYNTHIA LOUISE, NINKOVIC, SACHA, JALAIE, MEHRAN, ORR, SUVI TUULA MARJUKKA
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:This invention relates to compounds of Formula (I),or a pharmaceutically acceptable salt thereof, in which R-groups R1 to R23, A, Q, U, V, W, X, Y, Z, n, p and q are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject. La présente invention concerne des composés de formule (I), ou un sel pharmaceutiquement acceptable de ceux-ci, dans laquelle des groupes R, R1 à R23, A, Q, U, V, W, X, Y, Z, n, p et q sont tels que définis dans la description, des compositions pharmaceutiques comprenant de tels composés et sels, ainsi que des procédés d'utilisation de tels composés, sels et compositions pour le traitement d'une croissance cellulaire anormale, y compris le cancer, chez un sujet.