OXOACRIDINYL ACETIC ACID DERIVATIVES AND METHODS OF USE

OXOACRIDINYL ACETIC ACID DERIVATIVES AND METHODS OF USE

Compounds of Formula I or pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formula I as effective modulators of STING are also provided. L'invent...

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Bibliographische Detailangaben
Hauptverfasser: ALLEN, BRYCE K, MARINO, KRISTEN A, TAN, DAZHI, RICE, JAMES M, CHAMBERLAIN, BRIAN T, SHECHTER, SHARON, JERNIGAN, FINITH E, KULKARNI, MEGHANA M, SHERMAN, WOODY, LIN, ZHIXIONG
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Compounds of Formula I or pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formula I as effective modulators of STING are also provided. L'invention concerne des composés de formule I ou des sels ou esters pharmaceutiquement acceptables de ceux-ci capables de se lier à, et de moduler l'activité d'un stimulateur de protéine de stimulation de gènes d'interféron (STING). L'invention concerne également des procédés impliquant des composés de formule I en tant que modulateurs efficaces de STING.