USE OF SYNCYTIN FOR TARGETING DRUG AND GENE DELIVERY TO REGENERATING MUSCLE TISSUE

The invention relates to a pharmaceutical composition for targeting drug delivery including gene delivery to regenerating muscle tissue, comprising at least a therapeutic drug or gene, associated to a syncytin protein, and its use in the prevention and/or treatment of muscle injuries or diseases, in...

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Bibliographische Detailangaben
Hauptverfasser:	GALY, ANNE, FERRAND, MAXIME
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to a pharmaceutical composition for targeting drug delivery including gene delivery to regenerating muscle tissue, comprising at least a therapeutic drug or gene, associated to a syncytin protein, and its use in the prevention and/or treatment of muscle injuries or diseases, in particular in gene therapy of said diseases using lentiviral vector particles or lentivirus-like particles pseudotyped with syncytin protein. L'invention concerne une composition pharmaceutique permettant le ciblage de l'administration de médicaments, y compris l'administration de gènes, en vue de régénérer un tissu musculaire, comprenant au moins un médicament ou gène thérapeutiques, associés à une protéine de syncytine, ainsi que son utilisation dans la prévention et/ou le traitement de lésions ou de maladies musculaires, en particulier dans la thérapie génique desdites maladies à l'aide de particules de vecteurs lentiviraux ou de particules de type lentivirus pseudotypées avec la protéine de syncytine.