MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE
The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatmen...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | TAO, ZHI-FU BRAJE, WILFRIED JI, CHENG JANTOS, KATJA MICHAELIDES, MICHAEL LAI, CHUNQUI JUDD, ANDREW KLING, ANDREAS WANG, XILU KUNZER, AARON SONG, XIAOHONG TESKE, JESSC SULLIVAN, GERARD WENDT, MICHAEL MASTRACCHIO, ANTHONY POHLKI, FRAUKE SOUERS, ANDREW DOHERTY, GEORGE BRADY, PATRICK PENNING, THOMAS |
| description | The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
La présente invention concerne des composés de Formule (I) dans lesquels A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, et Y prennent l'une quelconque des valeurs définies dans la description, et des sels pharmaceutiquement acceptables de ceux-ci, qui sont utiles en tant qu'agents dans le traitement de maladies et d'états pathologiques, y compris le cancer. La présente invention concerne en outre des compositions pharmaceutiques comprenant des composés de Formule (I). |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CA3073114A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CA3073114A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CA3073114A13</originalsourceid><addsrcrecordid>eNrjZND3dXQO8neOdPbxdFbwdfbRNVTw9PPwdPIM8Q8KVnD0c1HwdQ3x8HcJVvB3UwgNduVhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfHOjsYG5saGhiaOhsZEKAEAkbolCQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE</title><source>esp@cenet</source><creator>TAO, ZHI-FU ; BRAJE, WILFRIED ; JI, CHENG ; JANTOS, KATJA ; MICHAELIDES, MICHAEL ; LAI, CHUNQUI ; JUDD, ANDREW ; KLING, ANDREAS ; WANG, XILU ; KUNZER, AARON ; SONG, XIAOHONG ; TESKE, JESSC ; SULLIVAN, GERARD ; WENDT, MICHAEL ; MASTRACCHIO, ANTHONY ; POHLKI, FRAUKE ; SOUERS, ANDREW ; DOHERTY, GEORGE ; BRADY, PATRICK ; PENNING, THOMAS</creator><creatorcontrib>TAO, ZHI-FU ; BRAJE, WILFRIED ; JI, CHENG ; JANTOS, KATJA ; MICHAELIDES, MICHAEL ; LAI, CHUNQUI ; JUDD, ANDREW ; KLING, ANDREAS ; WANG, XILU ; KUNZER, AARON ; SONG, XIAOHONG ; TESKE, JESSC ; SULLIVAN, GERARD ; WENDT, MICHAEL ; MASTRACCHIO, ANTHONY ; POHLKI, FRAUKE ; SOUERS, ANDREW ; DOHERTY, GEORGE ; BRADY, PATRICK ; PENNING, THOMAS</creatorcontrib><description>The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
La présente invention concerne des composés de Formule (I) dans lesquels A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, et Y prennent l'une quelconque des valeurs définies dans la description, et des sels pharmaceutiquement acceptables de ceux-ci, qui sont utiles en tant qu'agents dans le traitement de maladies et d'états pathologiques, y compris le cancer. La présente invention concerne en outre des compositions pharmaceutiques comprenant des composés de Formule (I).</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190221&DB=EPODOC&CC=CA&NR=3073114A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190221&DB=EPODOC&CC=CA&NR=3073114A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TAO, ZHI-FU</creatorcontrib><creatorcontrib>BRAJE, WILFRIED</creatorcontrib><creatorcontrib>JI, CHENG</creatorcontrib><creatorcontrib>JANTOS, KATJA</creatorcontrib><creatorcontrib>MICHAELIDES, MICHAEL</creatorcontrib><creatorcontrib>LAI, CHUNQUI</creatorcontrib><creatorcontrib>JUDD, ANDREW</creatorcontrib><creatorcontrib>KLING, ANDREAS</creatorcontrib><creatorcontrib>WANG, XILU</creatorcontrib><creatorcontrib>KUNZER, AARON</creatorcontrib><creatorcontrib>SONG, XIAOHONG</creatorcontrib><creatorcontrib>TESKE, JESSC</creatorcontrib><creatorcontrib>SULLIVAN, GERARD</creatorcontrib><creatorcontrib>WENDT, MICHAEL</creatorcontrib><creatorcontrib>MASTRACCHIO, ANTHONY</creatorcontrib><creatorcontrib>POHLKI, FRAUKE</creatorcontrib><creatorcontrib>SOUERS, ANDREW</creatorcontrib><creatorcontrib>DOHERTY, GEORGE</creatorcontrib><creatorcontrib>BRADY, PATRICK</creatorcontrib><creatorcontrib>PENNING, THOMAS</creatorcontrib><title>MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE</title><description>The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
La présente invention concerne des composés de Formule (I) dans lesquels A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, et Y prennent l'une quelconque des valeurs définies dans la description, et des sels pharmaceutiquement acceptables de ceux-ci, qui sont utiles en tant qu'agents dans le traitement de maladies et d'états pathologiques, y compris le cancer. La présente invention concerne en outre des compositions pharmaceutiques comprenant des composés de Formule (I).</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZND3dXQO8neOdPbxdFbwdfbRNVTw9PPwdPIM8Q8KVnD0c1HwdQ3x8HcJVvB3UwgNduVhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfHOjsYG5saGhiaOhsZEKAEAkbolCQ</recordid><startdate>20190221</startdate><enddate>20190221</enddate><creator>TAO, ZHI-FU</creator><creator>BRAJE, WILFRIED</creator><creator>JI, CHENG</creator><creator>JANTOS, KATJA</creator><creator>MICHAELIDES, MICHAEL</creator><creator>LAI, CHUNQUI</creator><creator>JUDD, ANDREW</creator><creator>KLING, ANDREAS</creator><creator>WANG, XILU</creator><creator>KUNZER, AARON</creator><creator>SONG, XIAOHONG</creator><creator>TESKE, JESSC</creator><creator>SULLIVAN, GERARD</creator><creator>WENDT, MICHAEL</creator><creator>MASTRACCHIO, ANTHONY</creator><creator>POHLKI, FRAUKE</creator><creator>SOUERS, ANDREW</creator><creator>DOHERTY, GEORGE</creator><creator>BRADY, PATRICK</creator><creator>PENNING, THOMAS</creator><scope>EVB</scope></search><sort><creationdate>20190221</creationdate><title>MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE</title><author>TAO, ZHI-FU ; BRAJE, WILFRIED ; JI, CHENG ; JANTOS, KATJA ; MICHAELIDES, MICHAEL ; LAI, CHUNQUI ; JUDD, ANDREW ; KLING, ANDREAS ; WANG, XILU ; KUNZER, AARON ; SONG, XIAOHONG ; TESKE, JESSC ; SULLIVAN, GERARD ; WENDT, MICHAEL ; MASTRACCHIO, ANTHONY ; POHLKI, FRAUKE ; SOUERS, ANDREW ; DOHERTY, GEORGE ; BRADY, PATRICK ; PENNING, THOMAS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3073114A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>TAO, ZHI-FU</creatorcontrib><creatorcontrib>BRAJE, WILFRIED</creatorcontrib><creatorcontrib>JI, CHENG</creatorcontrib><creatorcontrib>JANTOS, KATJA</creatorcontrib><creatorcontrib>MICHAELIDES, MICHAEL</creatorcontrib><creatorcontrib>LAI, CHUNQUI</creatorcontrib><creatorcontrib>JUDD, ANDREW</creatorcontrib><creatorcontrib>KLING, ANDREAS</creatorcontrib><creatorcontrib>WANG, XILU</creatorcontrib><creatorcontrib>KUNZER, AARON</creatorcontrib><creatorcontrib>SONG, XIAOHONG</creatorcontrib><creatorcontrib>TESKE, JESSC</creatorcontrib><creatorcontrib>SULLIVAN, GERARD</creatorcontrib><creatorcontrib>WENDT, MICHAEL</creatorcontrib><creatorcontrib>MASTRACCHIO, ANTHONY</creatorcontrib><creatorcontrib>POHLKI, FRAUKE</creatorcontrib><creatorcontrib>SOUERS, ANDREW</creatorcontrib><creatorcontrib>DOHERTY, GEORGE</creatorcontrib><creatorcontrib>BRADY, PATRICK</creatorcontrib><creatorcontrib>PENNING, THOMAS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TAO, ZHI-FU</au><au>BRAJE, WILFRIED</au><au>JI, CHENG</au><au>JANTOS, KATJA</au><au>MICHAELIDES, MICHAEL</au><au>LAI, CHUNQUI</au><au>JUDD, ANDREW</au><au>KLING, ANDREAS</au><au>WANG, XILU</au><au>KUNZER, AARON</au><au>SONG, XIAOHONG</au><au>TESKE, JESSC</au><au>SULLIVAN, GERARD</au><au>WENDT, MICHAEL</au><au>MASTRACCHIO, ANTHONY</au><au>POHLKI, FRAUKE</au><au>SOUERS, ANDREW</au><au>DOHERTY, GEORGE</au><au>BRADY, PATRICK</au><au>PENNING, THOMAS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE</title><date>2019-02-21</date><risdate>2019</risdate><abstract>The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
La présente invention concerne des composés de Formule (I) dans lesquels A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, et Y prennent l'une quelconque des valeurs définies dans la description, et des sels pharmaceutiquement acceptables de ceux-ci, qui sont utiles en tant qu'agents dans le traitement de maladies et d'états pathologiques, y compris le cancer. La présente invention concerne en outre des compositions pharmaceutiques comprenant des composés de Formule (I).</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_CA3073114A1 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T09%3A58%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=TAO,%20ZHI-FU&rft.date=2019-02-21&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECA3073114A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |