MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE

The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatmen...

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Bibliographische Detailangaben
Hauptverfasser:	TAO, ZHI-FU, BRAJE, WILFRIED, JI, CHENG, JANTOS, KATJA, MICHAELIDES, MICHAEL, LAI, CHUNQUI, JUDD, ANDREW, KLING, ANDREAS, WANG, XILU, KUNZER, AARON, SONG, XIAOHONG, TESKE, JESSC, SULLIVAN, GERARD, WENDT, MICHAEL, MASTRACCHIO, ANTHONY, POHLKI, FRAUKE, SOUERS, ANDREW, DOHERTY, GEORGE, BRADY, PATRICK, PENNING, THOMAS
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I). La présente invention concerne des composés de Formule (I) dans lesquels A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, et Y prennent l'une quelconque des valeurs définies dans la description, et des sels pharmaceutiquement acceptables de ceux-ci, qui sont utiles en tant qu'agents dans le traitement de maladies et d'états pathologiques, y compris le cancer. La présente invention concerne en outre des compositions pharmaceutiques comprenant des composés de Formule (I).