ANTI-CARBAMYLATED PROTEIN ANTIBODIES AND THE RISK FOR ARTHRITIS

Antibodies against citrullinated protein antigens (ACPA) have shown their relevance for the diagnosis and possibly pathogenesis in arthritis. The present invention provides means and methods for determining antibodies against homocitrulline containing proteins or carbamylated proteins/peptides (anti...

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Bibliographische Detailangaben
Hauptverfasser:	SHI, JING, VAN VEELEN, PETRUS ANTONIUS, TOES, REINALDUS EVERARDUS MARIA, HUIZINGA, THOMAS WILLEM JOHANNES, TROUW, LEENDERT ADRIANUS, CERAMI, ANTHONY
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
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Beschreibung
Zusammenfassung:	Antibodies against citrullinated protein antigens (ACPA) have shown their relevance for the diagnosis and possibly pathogenesis in arthritis. The present invention provides means and methods for determining antibodies against homocitrulline containing proteins or carbamylated proteins/peptides (anti-Car P) for the classification of individuals suffering from or at risk of suffering from arthritis. Il est décrit des anticorps anti-protéines citrullinées (ACPA) qui sont pertinents pour diagnostiquer larthrite et potentiellement réaliser la pathogenèse de larthrite Linvention concerne des moyens et des méthodes pour déterminer des anticorps dirigés contre des protéines contenant de lhomocitrulline ou des protéines carbamylées/peptides carbamylés (anti-Car P) pour établir un classement des personnes souffrant darthrite ou présentant des risques de souffrir de larthrite.