CRYSTALLINE FORMS OF PONATINIB HYDROCHLORIDE

The present invention provides novel crystalline forms of Ponatinib hydrochloride. Specific crystalline forms provided by the present invention include Ponatinib hydrochloride Form APO-I, APO-III and APO-IV, each of which is obtained from acetonitrile/formic acid solutions. Additionally, Form APO-V...

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Bibliographische Detailangaben
Hauptverfasser:	GORIN, BORIS, KHALILI, BAHAREH, SOUZA, FABIO E. S, REY, ALLAN W, BHATTACHARYYA, ANNYT, GERSTER, JENNY L, RANTANEN, KATHERINE A
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	The present invention provides novel crystalline forms of Ponatinib hydrochloride. Specific crystalline forms provided by the present invention include Ponatinib hydrochloride Form APO-I, APO-III and APO-IV, each of which is obtained from acetonitrile/formic acid solutions. Additionally, Form APO-V is provided, which is obtained from concentrated hydrochloric acid. La présente invention concerne de nouvelles formes cristallines du chlorhydrate de ponatinib. Les formes cristallines spécifiques fournies par la présente invention comprennent les formes APO-I, APO-III et APO-IV du chlorhydrate de ponatinib, chacune étant obtenue à partir de solutions d'acétonitrile/d'acide formique. L'invention concerne également la forme APO-V obtenue à partir de l'acide chlorhydrique concentré.