TRANSITION METAL-CATALYZED PROTODECARBOXYLATION OF .ALPHA.-HALO-ACRYLIC ACID DERIVATIVES

TRANSITION METAL-CATALYZED PROTODECARBOXYLATION OF .ALPHA.-HALO-ACRYLIC ACID DERIVATIVES

The present invention relates to a method for the synthesis of a halo olefin of formula (I) wherein Hal, R1, R2, R3, R4, X and Y are defined according to claim 1, or a salt thereof comprising the step of protodecarboxylation of an a-halo-acrylic acid derivative in the presence of a catalytic amount...

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Hauptverfasser: HAMPEL, THOMAS ARMIN, KOCH, SANDRA, SCHOERER, MARVIN, VOLCHKOV, IVAN N, REEVES, JONATHAN TIMOTHY, STANGE, CHRISTIAN, ZIMMERMANN, UWE JOHANNES, NORDSTROM, FREDRIK LARS, ZHONG, LI, REICHEL, CARSTEN, DANG, MAI THI QUYNH
Format: Patent
Sprache:eng ; fre
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to a method for the synthesis of a halo olefin of formula (I) wherein Hal, R1, R2, R3, R4, X and Y are defined according to claim 1, or a salt thereof comprising the step of protodecarboxylation of an a-halo-acrylic acid derivative in the presence of a catalytic amount of copper and/or silver. La présente invention concerne un procédé de synthèse d'une halo-oléfine de formule (I) dans laquelle Hal, R1, R2, R3, R4, X et Y sont tels que définis dans la revendication 1, ou un sel de celle-ci comprenant l'étape de protodécarboxylation d'un dérivé d'acide a-halo-acrylique en présence d'une quantité catalytique de cuivre et/ou d'argent.