ANTIBODIES TO ALPHA-SYNUCLEIN AND USES THEREOF

Disclosed herein are anti-a-synuclein antibodies which preferentially bind to oligomeric a-synuclein over monomeric a-synuclein, therapeutic compositions comprising the antibodies, and methods of using the antibodies to treat synucleinopathies. L'invention concerne des anticorps anti-a-synucléi...

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Hauptverfasser:	GRAEF, JOHN DAVID, MEREDITH, JERE ERNEST JR, HALK, EDWARD L, DEVIDZE, NINO, AHLIJANIAN, MICHAEL K
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein are anti-a-synuclein antibodies which preferentially bind to oligomeric a-synuclein over monomeric a-synuclein, therapeutic compositions comprising the antibodies, and methods of using the antibodies to treat synucleinopathies. L'invention concerne des anticorps anti-a-synucléine qui se lient de manière préférentielle à l'alpha-synucléine oligomère par rapport à l'alpha-synucléine monomère, des compositions thérapeutiques comprenant les anticorps, et des procédés d'utilisation des anticorps pour traiter des synucléinopathies.