CRYSTALLINE FORMS OF 4-(2-((1R,2R)-2-HYDROXYCYCLOHEXYLAMINO) BENZOTHIAZOL-6-YLOXY)-N-METHYLPICOLINAMIDE

This application relates to various crystalline forms of 4-(2-((1R,2R)-2-hydroxycyclohexylamino)benzothiazol-6-yloxy)-N-methylpicolinamide hydrochloride salts as well as compositions and methods of using the same. In some embodiments the crystalline forms also contain water ("hydrates"). T...

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Hauptverfasser:	WAYKOLE, LILADHAR MURLIDHAR, GRANDEURY, ARNAUD
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	This application relates to various crystalline forms of 4-(2-((1R,2R)-2-hydroxycyclohexylamino)benzothiazol-6-yloxy)-N-methylpicolinamide hydrochloride salts as well as compositions and methods of using the same. In some embodiments the crystalline forms also contain water ("hydrates"). These materials are useful in the treatment of various diseases, including glioblastoma multiforme, breast cancer, pancreatic cancer and other solid tumors. La présente invention concerne diverses formes cristallines du sel 4- (2- ((1R,2R)-2-hydroxycyclohexylamino) benzothiazol-6-yloxy)-N-méthylpicolinamide, ainsi que des compositions et des procédés d'utilisation de ceux-ci. Dans certains modes de réalisation, les formes cristallines contiennent également de l'eau ("hydrates"). Ces matériaux sont utiles dans le traitement de diverses maladies, y compris le glioblastome multiforme, le cancer du sein, le cancer du pancréas et d'autres tumeurs solides.