COMPOUNDS AND METHODS FOR THE TREATMENT OF TROP2 POSITIVE DISEASES

Disclosed herein are anti-TROP2 antibodies conjugated with maytansinoid drugs for targeted delivery to disease tissues. Methods relating to the preparation and uses of such drug conjugates to treat TROP2 positive cells in cancers are provided. L'invention concerne des anticorps anti-TROP2 conju...

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Bibliographische Detailangaben
Hauptverfasser:	HUANG, XIAOYANG, OU, ZIQIANG, LI, SHENGFENG, YU, JINN, QIN, CHAO, TANG, WEIJIA, PENG, XIAN, YANG, YILI
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein are anti-TROP2 antibodies conjugated with maytansinoid drugs for targeted delivery to disease tissues. Methods relating to the preparation and uses of such drug conjugates to treat TROP2 positive cells in cancers are provided. L'invention concerne des anticorps anti-TROP2 conjugués à des médicaments maytansinoïdes pour l'administration ciblée dans des tissus malades. L'invention concerne également des méthodes relatives à la préparation et aux utilisations de ces conjugués médicamenteux pour traiter les cancers à cellules TROP2 positives.