COMPOSITIONS AND METHODS FOR DELIVERING MESSENGER RNA

The present invention provides compositions comprising nucleic acid molecules, such as mRNA molecules, encapsulated within lipid particles. The compositions are useful, for example, to introduce the mRNA molecules into a human subject where they are translated to produce a polypeptide that functions...

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Bibliographische Detailangaben
Hauptverfasser:	ABRAMS, MICHAEL J, HEYES, JAMES, YAWORSKI, EDWARD D, PALMER, LORNE RALPH, JUDGE, ADAM, LAM, KIEU MONG, REID, STEPHEN P
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides compositions comprising nucleic acid molecules, such as mRNA molecules, encapsulated within lipid particles. The compositions are useful, for example, to introduce the mRNA molecules into a human subject where they are translated to produce a polypeptide that functions to ameliorate one or more symptoms of a disease. La présente invention concerne des compositions comprenant des molécules d'acide nucléique, telles que des molécules d'ARNm, encapsulées dans des particules lipidiques. Les compositions sont utiles, par exemple, pour introduire les molécules d'ARNm dans un sujet humain où elles sont traduites pour produire un polypeptide qui agit de manière à améliorer un ou plusieurs symptômes d'une maladie.