COMPOSITIONS COMPRISING 5-CHOLESTEN-3, 25-DIOL, 3-SULFATE (25HC3S) OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND AT LEAST ONE CYCLIC OLIGOSACCHARIDE

COMPOSITIONS COMPRISING 5-CHOLESTEN-3, 25-DIOL, 3-SULFATE (25HC3S) OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND AT LEAST ONE CYCLIC OLIGOSACCHARIDE

Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25HC3S) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide, e.g., a cyclodextrin (CD), are provided. The compositions may be used to prevent and/or treat a variety of diseases and conditions, including organ...

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Bibliographische Detailangaben
Hauptverfasser: KIM, MEEJ, WU, HONGWEI, NING, YANXIA, LEE, MIN L, XU, LEYUAN, REN, SHUNLIN, KIM, JIN KOUNG, MIKSZTAL, ANDREW R, TAMRAZ, WILMA, LIN, WEIQI
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Zusammenfassung:Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25HC3S) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide, e.g., a cyclodextrin (CD), are provided. The compositions may be used to prevent and/or treat a variety of diseases and conditions, including organ failure (e.g. acute liver failure), high cholesterol/high lipids, and various inflammatory diseases and conditions. L'invention concerne des compositions comprenant du 5-cholestène -3, 25-diol, 3-sulfate (25 HC3S) ou un sel pharmaceutiquement acceptable de celui-ci et au moins un oligosaccharide cyclique, par exemple, une cyclodextrine (CD). Les compositions peuvent être utilisées pour prévenir et/ou traiter diverses maladies et divers états pathologiques, y compris l'insuffisance d'organe (par exemple, l'insuffisance hépatique aiguë), les taux élevés de cholestérol/de lipides, et diverses maladies et états inflammatoires.