THIAZOLE DERIVATIVES USEFUL AS MUTANT IDH1 INHIBITORS FOR TREATING CANCER

THIAZOLE DERIVATIVES USEFUL AS MUTANT IDH1 INHIBITORS FOR TREATING CANCER

A compound of Formula II or a pharmaceutically acceptable salt thereof, wherein CyN is a cyclic amine group bound via a nitrogen atom; X is C or N; R1 and R2 are each independently a halogen, CN, CF3, CHF2, CH2F, a C1-C10alkyl group, a C1-C10alkoxy group, a di(C1-C5alkyl)amino; m and n are each inde...

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Hauptverfasser: WANG, XIAODONG, PRAGANI, RAJAN, ROHDE, JASON MATTHEW, EMILY DAVIS, MINDY IRENE, BOXER, MATTHEW BRIAN, MCIVER, ANDREW LOUIS, SIMEONOV, ANTON, BRIMACOMBE, KYLE RYAN, FANG, YUHONG, HALL, MATTHEW, JADHAV, AJIT, KARAVADHI, SURENDRA, MARTINEZ, NATALIA, LIU, LI, SHEN, MIN, ZHAO, WEI
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:A compound of Formula II or a pharmaceutically acceptable salt thereof, wherein CyN is a cyclic amine group bound via a nitrogen atom; X is C or N; R1 and R2 are each independently a halogen, CN, CF3, CHF2, CH2F, a C1-C10alkyl group, a C1-C10alkoxy group, a di(C1-C5alkyl)amino; m and n are each independently 1, 2, or 3, and represents either a single bond or a double bond, wherein the racemic mixture of 3-(4-(4-chlorophenyl)thiazol-2-yl)-1-(2-ethyl-5-methoxyphenyl)-6-(2-methylprop-1-en-1-yl)-5-(piperazine-1-carbonyl)pyridin-2(1H)-one atropisomers is excluded. Un composant de la formule II ou d'un sel pharmaceutiquement accepté de celui-ci, où CyN est un groupe d'amine cyclique lié par un atome d'hydrogène; X est C ou N; R1 et R2 sont chacun indépendant d'un halogène, CN, CF3, CHF2, CH2F, a C1-C10 groupe alkyle, a C1-C10 groupe alkoxy, a di(C1-C5alkyle)amino;m et n sont chacun indépendant de 3-(4-(4-chlorophényle)thiazole-2-yl)-1-(2-éthyle-5-méthoxyphenyle)-6-(2-méthylprop-1-en-1-yl)-5-(piperazine-1-carbonyl)pyridine-2(1H)-un atropisomère est exclu.