POLYMERASE VARIANTS AND USES THEREOF

Described herein is a variant pol6 polymerase having at least one mutation selected from H223, N224, Y225, H227,1295, Y342, T343, 1357, S360, L361,1363, S365, S366, Y367, P368, D417, E475, Y476, F478, K518, H527, T529, M531, N535, G539, P542, N545, 0546, A547, L549,1550, N552, G553, F558, A596, G603...

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Bibliographische Detailangaben
Hauptverfasser: MCGAW, COLIN, LEDERMAN, ILYA, AYER, ARUNA, ARNOLD, CLEOMA, SHULTZ, TYLER, SCHWAB, CHARLES, THAI, EILEEN
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:Described herein is a variant pol6 polymerase having at least one mutation selected from H223, N224, Y225, H227,1295, Y342, T343, 1357, S360, L361,1363, S365, S366, Y367, P368, D417, E475, Y476, F478, K518, H527, T529, M531, N535, G539, P542, N545, 0546, A547, L549,1550, N552, G553, F558, A596, G603, A610, V615, Y622, C623, D624,1628, Y629, R632, N635, M641, A643,1644, T647, 1648, T651,1652, K655, W656, D657, V658, H660, F662, L690 and combinations thereof. Il est décrit une variante pol6 polymérase ayant au moins une mutation parmi les suivantes ou une combinaison de celles-ci : H223, N224, Y225, H227,1295, Y342, T343, 1357, S360, L361,1363, S365, S366, Y367, P368, D417, E475, Y476, F478, K518, H527, T529, M531, N535, G539, P542, N545, 0546, A547, L549,1550, N552, G553, F558, A596, G603, A610, V615, Y622, C623, D624,1628, Y629, R632, N635, M641, A643,1644, T647, 1648, T651,1652, K655, W656, D657, V658, H660, F662, L690.