EXTRACELLULAR VESICLES WITH ENHANCED POTENCY

Provided are methods for isolating potent extracellular vesicle or exosome populations from mesenchymal stromal cells, and the use of the isolated extracellular vesicles or exosomes in treating vasculopathy, including pulmonary hypertension, bronchopulmonary dysplasia, and disease and conditions ass...

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Bibliographische Detailangaben
Hauptverfasser:	ILAGAN, ROGER MARQUEZ, CHEADLE, JOHN, RODRIGUEZ, MARIA PIA, MEDRANO, CAROLINA, HOGAN, SARAH
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Provided are methods for isolating potent extracellular vesicle or exosome populations from mesenchymal stromal cells, and the use of the isolated extracellular vesicles or exosomes in treating vasculopathy, including pulmonary hypertension, bronchopulmonary dysplasia, and disease and conditions associated with mitochondrial dysfunction. L'invention concerne des procédés permettant d'isoler des populations actives de vésicules extracellulaires ou d'exosomes à partir de cellules stromales mésenchymateuses, et l'utilisation des vésicules extracellulaires ou des exosomes isolés dans le traitement d'une vasculopathie, y compris d'une hypertension pulmonaire, d'une dysplasie bronchopulmonaire, et d'une maladie et d'états pathologiques associés à un dysfonctionnement mitochondrial.