COMPOSITIONS AND METHODS FOR THE PRODUCTION OF COMPOUNDS

COMPOSITIONS AND METHODS FOR THE PRODUCTION OF COMPOUNDS

The present disclosure provides nucleic acids encoding a Large ATP-binding regulator of the LuxR family (LAL) of transcription factors, vectors and host cells including such nucleic acids, and methods for producing compounds (e.g., polyketides or ß-lactam compounds) with such nucleic acids, vectors,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: VERDINE, GREGORY L, MORGENSTERN, JAY P, FOULSTON, LUCY, BLODGETT, JOSHUA A.V, GRAY, DANIEL C, ROBISON, KEITH, BOWMAN, BRIAN R
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present disclosure provides nucleic acids encoding a Large ATP-binding regulator of the LuxR family (LAL) of transcription factors, vectors and host cells including such nucleic acids, and methods for producing compounds (e.g., polyketides or ß-lactam compounds) with such nucleic acids, vectors, and/or host cells. La présente invention concerne des acides nucléiques codant pour un régulateur de la famille LAL (Large ATP-binding regulator of the LuxR family) de facteurs de transcription, des vecteurs et des cellules hôtes comprenant de tels acides nucléiques, et des procédés pour produire des composés (par exemple des polycétides ou des composés de ß-lactame) avec de tels acides nucléiques, vecteurs et/ou cellules hôtes.