NOVEL COMPOUNDS AS AUTOTAXIN INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME

The present invention relates to compounds represented by the general chemical formula 1: where X is CH; Y is N; R is indanyl; and Q is an optionally substituted five-membered heteroarylene having 2 or 3 heteroatoms selected from nitrogen, oxygen and sulfur. Also disclosed are pharmaceutical compositions containing the same. The compounds are useful as autotaxin inhibitors for treatment or prophylaxis of a condition or disorder caused by autotaxin activation or increased concentration of lysophosphatidic acid. The novel autotaxin inhibitors, by inhibiting the production of lysophosphatidic acid, are useful for treatment or prophylaxis of cardiovascular disorder, cancer, metabolic disorder, kidney disorder, liver disorder, inflammatory disorder, nervous system disorder, respiratory system disorder, fibrotic disease, ocular disorder, cholestatic and other forms of chronic pruritus, or acute or chronic organ transplant rejection.