PIPERIDINE DERIVATIVE AND METHODS OF USE THEREOF

The present invention provides N-[1-(1-Cyclohexyl-3,5-dimethyl-1H-pyrazole-4-sulfonyl)-4-phenyl-piperidin-4-ylmethyl]-N-isobutyl-4-{[(piperidin-4-ylmethyl)-amino]-methyl}-benzenesulfonamide and pharmaceutically acceptable salts thereof. These compounds may be useful in the treatment of diseases such...

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Bibliographische Detailangaben
Hauptverfasser:	HARI, ANITHA, CHRISTEN, DANIEL P, BANNER, WILLIAM KENNETH, GOWDA, RAJU BORE, POLISETTI, DHARMA RAO, GUPTA, SUPARNA, MJALLI, ADNAN M.M, GADDAM, BAPU, ANDREWS, ROBERT CARL
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides N-[1-(1-Cyclohexyl-3,5-dimethyl-1H-pyrazole-4-sulfonyl)-4-phenyl-piperidin-4-ylmethyl]-N-isobutyl-4-{[(piperidin-4-ylmethyl)-amino]-methyl}-benzenesulfonamide and pharmaceutically acceptable salts thereof. These compounds may be useful in the treatment of diseases such as Alzheimer's disease or renal failure. The present invention further relates to methods for the preparation of compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use of such compounds and/or pharmaceutical compositions in treating certain diseases. La présente invention concerne un N-[1-(1-cyclohexyl-3,5-diméthyl-1H-pyrazole-4-sulfonyl)-4-phényl-pipéridin-4-ylméthyl]-N-isobutyl-4-{[(pipéridin-4-ylméthyl)-amino]-méthyl}-benzènesulfonamide et des sels pharmaceutiquement acceptables de celui-ci. Ces composés peuvent être utiles dans le traitement de maladies telles que la maladie d'Alzheimer ou une insuffisance rénale. L'invention concerne en outre des procédés de préparation de composés représentés par la formule (I) et des sels pharmaceutiquement acceptables de ceux-ci, des compositions pharmaceutiques comprenant de tels composés, et l'utilisation de tels composés et/ou compositions pharmaceutiques dans le traitement de certaines maladies.