C-3 AND C-17 MODIFIED TRITERPENOIDS AS HIV-1 INHIBITORS

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula (I). These compou...

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Bibliographische Detailangaben
Hauptverfasser:	CHEN, JIE, DICKER, IRA B, VENABLES, BRIAN LEE, REGUEIRO-REN, ALICIA, CHEN, YAN, SIN, NY, HARTZ, RICHARD A, NOWICKA-SANS, BEATA, SWIDORSKI, JACOB, MEANWELL, NICHOLAS A, SIT, SING-YUEN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS STEROIDS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula (I). These compounds are useful for the treatment of HIV and AIDS. La présente invention concerne des composés ayant des propriétés thérapeutiques et bioactives, leurs compositions pharmaceutiques et leurs procédés d'utilisation. L'invention concerne, en particulier, des dérivés de l'acide bétulinique ayant une activité antivirale unique, qui sont utilisés comme inhibiteurs de maturation du VIH, tels que représentés par des composés de formule I : Ces composés s'avèrent utiles dans le traitement du VIH et du SIDA.