METHODS FOR INHIBITING CONVERSION OF CARNITINE TO TRIMETHYLAMINE (TMA)

The invention provides a method of inhibiting the conversion of carnitine to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual one or more compositions comprising a compound set forth in Formula (I) wherein the compound is administered in an amount ef...

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Bibliographische Detailangaben
Hauptverfasser:	HAZEN, STANLEY LEON, REED, JODIE MICHELLE, WOS, JOHN AUGUST, GARCIA-GARCIA, JOSE CARLOS, STANTON, DAVID THOMAS, CODY, DAVID BLAIR, GERBERICK, GEORGE FRANKLIN, DEUTSCH, ANGELA JANE, INGLIN, THOMAS ALFRED, REILLY, MICHAEL
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides a method of inhibiting the conversion of carnitine to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual one or more compositions comprising a compound set forth in Formula (I) wherein the compound is administered in an amount effective to inhibit conversion of carnitine to TMA in the individual. L'invention concerne un procédé pour inhiber la conversion de la carnitine en triméthylamine (TMA) et abaisser le TMAO chez un sujet, comprenant l'administration audit sujet d'une ou de plusieurs compositions comprenant un composé représenté par la Formule (I) : le composé étant administré en une quantité efficace pour inhiber la conversion de la carnitine en TMA chez le sujet.