1,3,4-THIADIAZOLE COMPOUNDS AND THEIR USE IN TREATING CANCER

A compound of Formula (I) or a pharmaceutically acceptable salt thereof, is described. Q can be pyridazin-3-yl, 6- fluoropyridazin-3-yl; R1 can be H; R2 and R3 can each independently be C1-C6 alkyl, or R2 and R3 taken together are -(CH2)3; or R1 and R2 taken together can be -(CH2)2- and R3 can be -C...

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Bibliographische Detailangaben
Hauptverfasser:	SMITH, PETER DUNCAN, PERKINS, DAVID ROBERT, FINLAY, MAURICE RAYMOND VERSCHOYLE, BAILEY, ANDREW, NISSINK, JOHANNES WILHELMUS MARIA, RAUBO, PIOTR ANTONI
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A compound of Formula (I) or a pharmaceutically acceptable salt thereof, is described. Q can be pyridazin-3-yl, 6- fluoropyridazin-3-yl; R1 can be H; R2 and R3 can each independently be C1-C6 alkyl, or R2 and R3 taken together are -(CH2)3; or R1 and R2 taken together can be -(CH2)2- and R3 can be -CH3; R4 halo, -CH3, -OCH3, -OCHF2, -OCF3, or -CN; and n can be 0, 1, or 2. The compound of formula (I) can inhibit glutaminase, e.g., GLS1. L'invention concerne un composé de formule (I) ou son sel pharmaceutiquement acceptable. Dans la formule, Q peut être pyridazin-3-yl, 6-fluoropyridazin-3-yl ; R1 peut être H ; R2 et R3 peuvent être chacun indépendamment alkyle en C1-C6, ou R2 et R3 forment ensemble -(CH2)3 ; ou R1 et R2 peuvent former ensemble -(CH2)2- et R3 peut être -CH3 ; R4 halo, -CH3, -OCH3, -OCHF2, -OCF3, ou -CN ; et n peut être 0, 1 ou 2. Le composé de formule (I) peut inhiber une glutaminase, par exemple GLS1.