APPARATUS AND PROCESS FOR THE AUTOMATED CHEMICAL SYNTHESIS OF COMPOUNDS

The present invention relates to an apparatus for the automated synthesis of at least one chemical compound, in particular for compounds comprising at least one Nheterocyclic structure, comprising at least one cartridge comprising at least one first compartment for providing at least one first reage...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WANNER, BENEDIKT MATTHIAS, CHEN, KUANG-YEN, NICHOLS, PAULA LOUISE, BODE, JEFFREY WILLIAM, PATTABIRAMAN, VIJAYA
Format: Patent
Sprache:eng ; fre
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Beschreibung
Zusammenfassung:The present invention relates to an apparatus for the automated synthesis of at least one chemical compound, in particular for compounds comprising at least one Nheterocyclic structure, comprising at least one cartridge comprising at least one first compartment for providing at least one first reagent for the chemical synthesis of the at least one compound; at least one second compartment for providing at least one second reagent for the chemical synthesis of the at least one compound, and at least one third compartment for purifying the at least one synthesized compound; at least one reaction container for providing the compounds to be fed into at least one of the compartments of the cartridge and/or collecting the reaction product from at least one of the compartments of the cartridge; at least one solvent container for storing the solvent systems used for at least one of the compartments of the cartridge; optionally at least one waste container for collecting the waste from at least one of the compartments of the cartridge, in particular one separate waste container for each of the at least three compartments; at least two flow patch selecting valve, wherein at least one first valve selects the liquid source, in particular reaction container or solvent reservoir, and the at least one second valve directs the liquid to one of the compartments in the cartridge, reaction container or optional waste container, and at least one pump arranged downstream of the at least one first valve and upstream of the at least one second valve. The present invention relates also to a process for the automated synthesis of a chemical compound using such an apparatus. La présente invention concerne un appareil pour la synthèse automatisée d'au moins un composé chimique, en particulier des composés comprenant au moins une structure Nhétérocyclique, comprenant au moins une cartouche comportant au moins un premier compartiment pour fournir au moins un premier réactif pour la synthèse chimique dudit composé; au moins un deuxième compartiment pour fournir au moins un second réactif pour la synthèse chimique dudit composé, et au moins un troisième compartiment pour purifier ledit composé synthétisé; au moins une cuve de réaction pour fournir les composés à acheminer dans au moins un des compartiments de la cartouche et/ou collecter le produit de réaction provenant d'au moins un des compartiments de la cartouche; au moins un contenant de solvant pour stocker les systèmes de solvant