PYRIMIDINE DERIVATIVE AND USE THEREOF

PYRIMIDINE DERIVATIVE AND USE THEREOF

The present invention provides a pyrimidine derivative and a use thereof. The pyrimidine derivative is the compound shown in formula I or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein, R1, R2, R3, R4 and R5 are, for example, as defined in the specificat...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ZHANG, XIAOLIN, XIA, HANGUI, YANG, ZHONGWEN, WANG, XUEHAI, HUANG, LU, XU, YONG, YUE, YANG, SHENG, XIJUN, XIAO, QIANG
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides a pyrimidine derivative and a use thereof. The pyrimidine derivative is the compound shown in formula I or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein, R1, R2, R3, R4 and R5 are, for example, as defined in the specification. The compound can act as an ALK inhibitor, and is for preparing an anti-tumor medicament for suppressing an anaplastic lymphoma kinase. (see formula I) La présente invention concerne un dérivé pyrimidine et son utilisation. Le dérivé pyrimidine est le composé présenté dans la formule I ou son sel, hydrate, solvate, métabolite ou promédicament pharmaceutiquement acceptable, où, R1, R2, R3, R4 et R5 sont, par exemple, tels que définis dans la description. Le composé peut agir comme inhibiteur ALK, et sert à la préparation d'un médicament anti-tumoral pour la suppression d'une kinase du lymphome anaplasique.