ANTIBIOTIC COMPOUNDS, PHARMACEUTICAL FORMULATIONS THEREOF AND METHODS AND USES THEREFOR

The present invention relates to compounds of formula (I) wherein G1 to G8 are as defined herein. The compounds are PK inhibitors and as such represent a new approach to treating pathogenic infections, including multidrug resistant pathogens. Disclosed herein are the compounds of formula (I), pharma...

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Bibliographische Detailangaben
Hauptverfasser:	HSIEH, TOM HAN HSIAO, YOUNG, ROBERT NORMAN, JAQUITH, JAMES BRIAN, MANDEL, ALEXANDER LAURENCE, SHIDMOOSSAVEE, FAHIMEH S, KUMAR, NAG SHARWAN, DULLAGHAN, EDITH MARY, TAN, JASON SAMUEL
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds of formula (I) wherein G1 to G8 are as defined herein. The compounds are PK inhibitors and as such represent a new approach to treating pathogenic infections, including multidrug resistant pathogens. Disclosed herein are the compounds of formula (I), pharmaceutical compositions comprising the compounds of formula (I) and their use in the treatment of antimicrobial infection. (Formula (1)) La présente invention concerne des composés de formule (I), dans laquelle G1 à G8 sont tels que définis dans la description. Les composés sont des inhibiteurs de PK et représentent, à ce titre, une nouvelle approche pour traiter les infections pathogènes, dont les agents pathogènes résistants à plusieurs médicaments. Sont divulgués ici les composés de formule (I), des compositions pharmaceutiques comprenant les composés de formule (I) et leur utilisation dans le traitement d'infections microbiennes. (Formule (1))