BENZIMIDAZOLYL DERIVATIVES FOR USE AS FERROPORTIN INHIBITORS
The invention relates to novel ferroportin inhibitors of the general formula (I) pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particula...
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| creator | BUHR, WILM PENA, PAULA SCOTT, JOHN DURRENBERGER, FRANZ SHEPHERD, JON REIM, STEFAN KALOGERAKIS, ARIS LECCI, CRISTINA BURCKHARDT, SUSANNA JARJES-PIKE, RICHARD MANOLOVA, VANIA BURGERT, MICHAEL BOYCE, SUSAN YARNOLD, CHRISTOPHER JOHN |
| description | The invention relates to novel ferroportin inhibitors of the general formula (I) pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia and hemochromatosis.
L'invention concerne de nouveaux inhibiteurs de la ferroportine de formule générale (I), des compositions pharmaceutiques les contenant et leur utilisation comme médicaments, en particulier pour la prophylaxie et/ou le traitement de maladies provoquées par un manque d'hepcidine ou des troubles du métabolisme du fer, comme c'est le cas tout particulièrement des états de surcharge de fer tels que notamment la thalassémie et l'hémochromatose. |
| format | Patent |
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L'invention concerne de nouveaux inhibiteurs de la ferroportine de formule générale (I), des compositions pharmaceutiques les contenant et leur utilisation comme médicaments, en particulier pour la prophylaxie et/ou le traitement de maladies provoquées par un manque d'hepcidine ou des troubles du métabolisme du fer, comme c'est le cas tout particulièrement des états de surcharge de fer tels que notamment la thalassémie et l'hémochromatose.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231024&DB=EPODOC&CC=CA&NR=3002416C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231024&DB=EPODOC&CC=CA&NR=3002416C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BUHR, WILM</creatorcontrib><creatorcontrib>PENA, PAULA</creatorcontrib><creatorcontrib>SCOTT, JOHN</creatorcontrib><creatorcontrib>DURRENBERGER, FRANZ</creatorcontrib><creatorcontrib>SHEPHERD, JON</creatorcontrib><creatorcontrib>REIM, STEFAN</creatorcontrib><creatorcontrib>KALOGERAKIS, ARIS</creatorcontrib><creatorcontrib>LECCI, CRISTINA</creatorcontrib><creatorcontrib>BURCKHARDT, SUSANNA</creatorcontrib><creatorcontrib>JARJES-PIKE, RICHARD</creatorcontrib><creatorcontrib>MANOLOVA, VANIA</creatorcontrib><creatorcontrib>BURGERT, MICHAEL</creatorcontrib><creatorcontrib>BOYCE, SUSAN</creatorcontrib><creatorcontrib>YARNOLD, CHRISTOPHER JOHN</creatorcontrib><title>BENZIMIDAZOLYL DERIVATIVES FOR USE AS FERROPORTIN INHIBITORS</title><description>The invention relates to novel ferroportin inhibitors of the general formula (I) pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia and hemochromatosis.
L'invention concerne de nouveaux inhibiteurs de la ferroportine de formule générale (I), des compositions pharmaceutiques les contenant et leur utilisation comme médicaments, en particulier pour la prophylaxie et/ou le traitement de maladies provoquées par un manque d'hepcidine ou des troubles du métabolisme du fer, comme c'est le cas tout particulièrement des états de surcharge de fer tels que notamment la thalassémie et l'hémochromatose.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLBxcvWL8vT1dHGM8veJ9FFwcQ3yDHMM8QxzDVZw8w9SCA12VXAEMl2DgvwD_INCPP0UPP08PJ08Q_yDgnkYWNMSc4pTeaE0N4O8m2uIs4duakF-fGpxQWJyal5qSbyzo7GBgZGJoZmzMWEVAJ2fKRk</recordid><startdate>20231024</startdate><enddate>20231024</enddate><creator>BUHR, WILM</creator><creator>PENA, PAULA</creator><creator>SCOTT, JOHN</creator><creator>DURRENBERGER, FRANZ</creator><creator>SHEPHERD, JON</creator><creator>REIM, STEFAN</creator><creator>KALOGERAKIS, ARIS</creator><creator>LECCI, CRISTINA</creator><creator>BURCKHARDT, SUSANNA</creator><creator>JARJES-PIKE, RICHARD</creator><creator>MANOLOVA, VANIA</creator><creator>BURGERT, MICHAEL</creator><creator>BOYCE, SUSAN</creator><creator>YARNOLD, CHRISTOPHER JOHN</creator><scope>EVB</scope></search><sort><creationdate>20231024</creationdate><title>BENZIMIDAZOLYL DERIVATIVES FOR USE AS FERROPORTIN INHIBITORS</title><author>BUHR, WILM ; PENA, PAULA ; SCOTT, JOHN ; DURRENBERGER, FRANZ ; SHEPHERD, JON ; REIM, STEFAN ; KALOGERAKIS, ARIS ; LECCI, CRISTINA ; BURCKHARDT, SUSANNA ; JARJES-PIKE, RICHARD ; MANOLOVA, VANIA ; BURGERT, MICHAEL ; BOYCE, SUSAN ; YARNOLD, CHRISTOPHER JOHN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3002416C3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BUHR, WILM</creatorcontrib><creatorcontrib>PENA, PAULA</creatorcontrib><creatorcontrib>SCOTT, JOHN</creatorcontrib><creatorcontrib>DURRENBERGER, FRANZ</creatorcontrib><creatorcontrib>SHEPHERD, JON</creatorcontrib><creatorcontrib>REIM, STEFAN</creatorcontrib><creatorcontrib>KALOGERAKIS, ARIS</creatorcontrib><creatorcontrib>LECCI, CRISTINA</creatorcontrib><creatorcontrib>BURCKHARDT, SUSANNA</creatorcontrib><creatorcontrib>JARJES-PIKE, RICHARD</creatorcontrib><creatorcontrib>MANOLOVA, VANIA</creatorcontrib><creatorcontrib>BURGERT, MICHAEL</creatorcontrib><creatorcontrib>BOYCE, SUSAN</creatorcontrib><creatorcontrib>YARNOLD, CHRISTOPHER JOHN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BUHR, WILM</au><au>PENA, PAULA</au><au>SCOTT, JOHN</au><au>DURRENBERGER, FRANZ</au><au>SHEPHERD, JON</au><au>REIM, STEFAN</au><au>KALOGERAKIS, ARIS</au><au>LECCI, CRISTINA</au><au>BURCKHARDT, SUSANNA</au><au>JARJES-PIKE, RICHARD</au><au>MANOLOVA, VANIA</au><au>BURGERT, MICHAEL</au><au>BOYCE, SUSAN</au><au>YARNOLD, CHRISTOPHER JOHN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>BENZIMIDAZOLYL DERIVATIVES FOR USE AS FERROPORTIN INHIBITORS</title><date>2023-10-24</date><risdate>2023</risdate><abstract>The invention relates to novel ferroportin inhibitors of the general formula (I) pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia and hemochromatosis.
L'invention concerne de nouveaux inhibiteurs de la ferroportine de formule générale (I), des compositions pharmaceutiques les contenant et leur utilisation comme médicaments, en particulier pour la prophylaxie et/ou le traitement de maladies provoquées par un manque d'hepcidine ou des troubles du métabolisme du fer, comme c'est le cas tout particulièrement des états de surcharge de fer tels que notamment la thalassémie et l'hémochromatose.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | BENZIMIDAZOLYL DERIVATIVES FOR USE AS FERROPORTIN INHIBITORS |
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