METHOD FOR PURIFYING BENZOPYRAN DERIVATIVE, CRYSTAL FORM THEREOF, AND METHOD FOR PREPARING CRYSTAL FORM
The present invention provides a method for purifying (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran, comprising converting amorphous (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-...
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| creator | PARK, YONG-KYUN RYU, JAEUN KIM, HYUN-KYU SHIN, DONG-YEOP |
| description | The present invention provides a method for purifying (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran, comprising converting amorphous (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran into a crystal form thereof. In addition, the present invention provides: a novel crystal form of the (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran; and a preparation method therefor.
La présente invention concerne un procédé de purification de(2R,3R,4S)-6-amino-4-[N-(4-chlorophényl)-N-(1H-imidazol-2-ylméthyl)-amino]-3-hydroxy-2-méthyl-2-diméthoxyméthyl-3,4-dihydro-2H-1-benzopyrane, comprenant la conversion de (2R,3R,4S)-6-amino-4-[N-(4-chlorophényl)-N-(1H-imidazol-2-ylméthyl)-amino]-3-hydroxy-2-méthyl-2-diméthoxyméthyl-3,4-dihydro-2H-1-benzopyrane amorphe en une forme cristalline. De plus, la présente invention concerne : une nouvelle forme cristalline du (2R,3R,4S)-6-amino-4-[N-(4-chlorophényl)-N-(1H-imidazol-2-ylméthyl)-amino]-3-hydroxy-2-méthyl-2-diméthoxyméthyl-3,4-dihydro -2H-1-benzopyrane ; et un procédé de préparation correspondant. |
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La présente invention concerne un procédé de purification de(2R,3R,4S)-6-amino-4-[N-(4-chlorophényl)-N-(1H-imidazol-2-ylméthyl)-amino]-3-hydroxy-2-méthyl-2-diméthoxyméthyl-3,4-dihydro-2H-1-benzopyrane, comprenant la conversion de (2R,3R,4S)-6-amino-4-[N-(4-chlorophényl)-N-(1H-imidazol-2-ylméthyl)-amino]-3-hydroxy-2-méthyl-2-diméthoxyméthyl-3,4-dihydro-2H-1-benzopyrane amorphe en une forme cristalline. De plus, la présente invention concerne : une nouvelle forme cristalline du (2R,3R,4S)-6-amino-4-[N-(4-chlorophényl)-N-(1H-imidazol-2-ylméthyl)-amino]-3-hydroxy-2-méthyl-2-diméthoxyméthyl-3,4-dihydro -2H-1-benzopyrane ; et un procédé de préparation correspondant.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170601&DB=EPODOC&CC=CA&NR=3001547A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25568,76551</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170601&DB=EPODOC&CC=CA&NR=3001547A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PARK, YONG-KYUN</creatorcontrib><creatorcontrib>RYU, JAEUN</creatorcontrib><creatorcontrib>KIM, HYUN-KYU</creatorcontrib><creatorcontrib>SHIN, DONG-YEOP</creatorcontrib><title>METHOD FOR PURIFYING BENZOPYRAN DERIVATIVE, CRYSTAL FORM THEREOF, AND METHOD FOR PREPARING CRYSTAL FORM</title><description>The present invention provides a method for purifying (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran, comprising converting amorphous (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran into a crystal form thereof. In addition, the present invention provides: a novel crystal form of the (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran; and a preparation method therefor.
La présente invention concerne un procédé de purification de(2R,3R,4S)-6-amino-4-[N-(4-chlorophényl)-N-(1H-imidazol-2-ylméthyl)-amino]-3-hydroxy-2-méthyl-2-diméthoxyméthyl-3,4-dihydro-2H-1-benzopyrane, comprenant la conversion de (2R,3R,4S)-6-amino-4-[N-(4-chlorophényl)-N-(1H-imidazol-2-ylméthyl)-amino]-3-hydroxy-2-méthyl-2-diméthoxyméthyl-3,4-dihydro-2H-1-benzopyrane amorphe en une forme cristalline. De plus, la présente invention concerne : une nouvelle forme cristalline du (2R,3R,4S)-6-amino-4-[N-(4-chlorophényl)-N-(1H-imidazol-2-ylméthyl)-amino]-3-hydroxy-2-méthyl-2-diméthoxyméthyl-3,4-dihydro -2H-1-benzopyrane ; et un procédé de préparation correspondant.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZEj3dQ3x8HdRcPMPUggIDfJ0i_T0c1dwcvWL8g-IDHL0U3BxDfIMcwzxDHPVUXAOigwOcfQBKfZVCPFwDXL1d9NRcPRzUUA2Jcg1wDEIZAqych4G1rTEnOJUXijNzaDg5hri7KGbWpAfn1pckJicmpdaEu_saGxgYGhqYu5oaEyEEgChJjTw</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>PARK, YONG-KYUN</creator><creator>RYU, JAEUN</creator><creator>KIM, HYUN-KYU</creator><creator>SHIN, DONG-YEOP</creator><scope>EVB</scope></search><sort><creationdate>20170601</creationdate><title>METHOD FOR PURIFYING BENZOPYRAN DERIVATIVE, CRYSTAL FORM THEREOF, AND METHOD FOR PREPARING CRYSTAL FORM</title><author>PARK, YONG-KYUN ; RYU, JAEUN ; KIM, HYUN-KYU ; SHIN, DONG-YEOP</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CA3001547A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>PARK, YONG-KYUN</creatorcontrib><creatorcontrib>RYU, JAEUN</creatorcontrib><creatorcontrib>KIM, HYUN-KYU</creatorcontrib><creatorcontrib>SHIN, DONG-YEOP</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PARK, YONG-KYUN</au><au>RYU, JAEUN</au><au>KIM, HYUN-KYU</au><au>SHIN, DONG-YEOP</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD FOR PURIFYING BENZOPYRAN DERIVATIVE, CRYSTAL FORM THEREOF, AND METHOD FOR PREPARING CRYSTAL FORM</title><date>2017-06-01</date><risdate>2017</risdate><abstract>The present invention provides a method for purifying (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran, comprising converting amorphous (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran into a crystal form thereof. In addition, the present invention provides: a novel crystal form of the (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran; and a preparation method therefor.
La présente invention concerne un procédé de purification de(2R,3R,4S)-6-amino-4-[N-(4-chlorophényl)-N-(1H-imidazol-2-ylméthyl)-amino]-3-hydroxy-2-méthyl-2-diméthoxyméthyl-3,4-dihydro-2H-1-benzopyrane, comprenant la conversion de (2R,3R,4S)-6-amino-4-[N-(4-chlorophényl)-N-(1H-imidazol-2-ylméthyl)-amino]-3-hydroxy-2-méthyl-2-diméthoxyméthyl-3,4-dihydro-2H-1-benzopyrane amorphe en une forme cristalline. De plus, la présente invention concerne : une nouvelle forme cristalline du (2R,3R,4S)-6-amino-4-[N-(4-chlorophényl)-N-(1H-imidazol-2-ylméthyl)-amino]-3-hydroxy-2-méthyl-2-diméthoxyméthyl-3,4-dihydro -2H-1-benzopyrane ; et un procédé de préparation correspondant.</abstract><oa>free_for_read</oa></addata></record> |
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| title | METHOD FOR PURIFYING BENZOPYRAN DERIVATIVE, CRYSTAL FORM THEREOF, AND METHOD FOR PREPARING CRYSTAL FORM |
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