METHOD FOR PURIFYING BENZOPYRAN DERIVATIVE, CRYSTAL FORM THEREOF, AND METHOD FOR PREPARING CRYSTAL FORM

The present invention provides a method for purifying (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran, comprising converting amorphous (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-...

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Bibliographische Detailangaben
Hauptverfasser:	PARK, YONG-KYUN, RYU, JAEUN, KIM, HYUN-KYU, SHIN, DONG-YEOP
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention provides a method for purifying (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran, comprising converting amorphous (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran into a crystal form thereof. In addition, the present invention provides: a novel crystal form of the (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran; and a preparation method therefor. La présente invention concerne un procédé de purification de(2R,3R,4S)-6-amino-4-[N-(4-chlorophényl)-N-(1H-imidazol-2-ylméthyl)-amino]-3-hydroxy-2-méthyl-2-diméthoxyméthyl-3,4-dihydro-2H-1-benzopyrane, comprenant la conversion de (2R,3R,4S)-6-amino-4-[N-(4-chlorophényl)-N-(1H-imidazol-2-ylméthyl)-amino]-3-hydroxy-2-méthyl-2-diméthoxyméthyl-3,4-dihydro-2H-1-benzopyrane amorphe en une forme cristalline. De plus, la présente invention concerne : une nouvelle forme cristalline du (2R,3R,4S)-6-amino-4-[N-(4-chlorophényl)-N-(1H-imidazol-2-ylméthyl)-amino]-3-hydroxy-2-méthyl-2-diméthoxyméthyl-3,4-dihydro -2H-1-benzopyrane ; et un procédé de préparation correspondant.