METHOD OF SEPARATING STEREOISOMERS USING SUPERCRITICAL FLUID CHROMATOGRAPHY

A means of isolating specific stereoisomers and enantiomers from a complex mixture containing a possibility of 32 different stereoconfigurations, thus concentrating the stereoisomer or enantiomer to a high degree of purity. The separation is achieved using supercritical fluid chromatography, involvi...

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Bibliographische Detailangaben
Hauptverfasser:	HAUGHT, JOHN CHRISTIAN, SREEKRISHNA, KOTI TATACHAR, LEI, QINGXIN, MOTLAGH, SAFA, LIN, YAKANG, HOKE, STEVEN HAMILTON, REILLY, MICHAEL
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SEPARATION SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS TRANSPORTING
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Beschreibung
Zusammenfassung:	A means of isolating specific stereoisomers and enantiomers from a complex mixture containing a possibility of 32 different stereoconfigurations, thus concentrating the stereoisomer or enantiomer to a high degree of purity. The separation is achieved using supercritical fluid chromatography, involving a combination of Amylose tris [(S)-.alpha.-methylbenzylcarbamate] (AS-H) and Amylose tris (3,5-dimethylphenylcarbamate) (AD-H) columns. L'invention concerne un moyen d'isolement de stéréoisomères et d'énantiomères spécifiques à partir d'un mélange complexe contenant une possibilité de 32 stéréoconfigurations différentes, permettant ainsi la concentration dun stéréoisomère ou d'un énantiomère à un degré de pureté élevé.