INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 AND TDO) AND THEIR USE IN THERAPY

Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxid...

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Bibliographische Detailangaben
Hauptverfasser:	PALMER, BRIAN DESMOND, CHING, LAI-MING
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer. L'invention concerne des compositions pharmaceutiques comprenant des composés 3-amino-isoxazolopyridines de formule I ayant une activité inhibitrice d'IDO1 et/ou de TDO, dans laquelle W représente CR1, N ou N-oxyde; X représente CR2, N ou N-oxyde; Y représente CR3, N ou N-oxyde; Z représente CR4, N ou N-oxyde; et W, X, Y et/ou Z représentent N ou N-oxyde; et R9 et R10 sont tels que définis. L'invention concerne également des méthodes d'utilisation de tels composés dans le traitement de diverses affections, telles que le cancer.