NICOTINAMIDE MONONUCLEOTIDE DERIVATIVES AND THEIR USES

The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotin...

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Bibliographische Detailangaben
Hauptverfasser:	SZCZEPANKIEWICZ, BRUCE, NORMINGTON, KARL D, LIVINGSTON, DAVID, MCKEARIN, JAMES M, SINCLAIR, DAVID A, KREMSKY, JONATHAN N
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival. L'invention concerne des compositions de dérivés de nicotinamide mononucléotide et leurs procédés d'utilisation. L'invention concerne également des procédés de préparation de dérivés de nicotinamide mononucléotide. L'invention concerne en outre des compositions pharmaceutiques et des compléments nutritionnels contenant un dérivé de nicotinamide mononucléotide . L'invention concerne enfin des procédés d'utilisation des dérivés de nicotinamide mononucléotide qui favorisent l'augmentation des niveaux intracellulaires du nicotinamide adénine dinucléotide (NAD+) dans des cellules et des tissus pour traiter des maladies et améliorer la survie tissulaire et cellulaire.