DELIVERY SYSTEMS FOR PROPOFOL

The present invention relates to a propofol-microemulsion comprising an oil phase in the form of oil droplets dispersed in an aqueous diluent continuous phase, wherein the oil phase comprises propofol, at least one surfactant comprising polyethylene glycol 15-hydroxystearate (Solutole HS 15), at least one solvent comprising medium-chain tiglycerides (MCT), at least one co-surfactant, and at least one co-solvent, the oil droplets having a size of at most 20 nm in the continuous phase, the propofol and the surfactant having diffusion coefficients having the same order of magnitude when in the microemulsion, and the microemulsion for parenteral administration, the weight ratio between said at least one solvent and the surfactant is between about 1:8 and 1:12, wherein the weight ratio between propofol and the surfactant is between about 1:5 and 1:12, and the microemulsion has a mono-disperse size distribution of oil droplets. La présente invention concerne de nouveaux systèmes d'administration pouvant être dilués et des micro-émulsions de propofol appropriées pour une administration intraveineuse de propofol.