TRICYCLIC DERIVATIVE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

TRICYCLIC DERIVATIVE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The present invention relates to a novel tricyclic derivative compound and, more specifically, to a tricyclic derivative compound having excellent inhibitory activity against PARP-1, tankyrase-1, or tankyrase-2, optical isomers thereof, a racemate thereof, or a pharmaceutically acceptable salt there...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LEE, HANCHANG, KIM, EUN SEON, KIM, JEONG-MIN, OH, HYEONGCHAN, CHUN, KWANGWOO, JANG, EUN SUNG, JOE, BO-YOUNG, LEE, HYUNHO, PARK, JISEON
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention relates to a novel tricyclic derivative compound and, more specifically, to a tricyclic derivative compound having excellent inhibitory activity against PARP-1, tankyrase-1, or tankyrase-2, optical isomers thereof, a racemate thereof, or a pharmaceutically acceptable salt thereof. The tricyclic derivative compound, optical isomers thereof, racemate thereof, or pharmaceutically acceptable salt thereof according to the present invention can be usefully used for the prevention or treatment of neuropathic pain, neurodegenerative diseases, cardiovascular diseases, diabetic neuropathy, inflammatory diseases, osteoporosis, or cancer through inhibitory activity against PARP-1, tankyrase-1, or tankyrase-2.